Method for treating skin wrinkles

ABSTRACT

The present invention relates to methods for treating acne and related pilosebaceous disorders with a safe and effective amount of salicylic acid and pantothenic acid or a pantothenic acid derivative. This combination of materials is found to be less irritating and drying to the skin than salicylic acid alone.

This is a continuation of application Ser. No. 08/422,012, filed on Apr.12, 1995, now U.S. Pat. No. 5,612,324, which is a continuation ofapplication Ser. No. 08/287,047, filed on Aug. 8, 1994, now abandoned,which is a continuation of application Ser. No. 08/141,434, filed onOct. 21, 1993, now abandoned which is a continuation of application Ser.No. 07/878,650, filed on May 5, 1992, now abandoned.

TECHNICAL FIELD

The present invention relates to methods for treating acne and relatedpilosebaceous disorders with a safe and effective amount of salicylicacid and pantothenic acid or a pantothenic acid derivative. Thiscombination is found to be less irritating and drying to the skin thansalicylic acid alone. In further embodiments, the present invention alsorelates to methods for regulating wrinkles and/or atrophy in mammalianskin by treatment with this combination.

BACKGROUND OF THE INVENTION

Acne is a common inflammatory pilosebaceous disease characterized bycomedones, papules, pustules, inflamed nodules, superficial pus-filledcysts, and in extreme cases, sinus formation and deep inflammation,sometimes associated with purulent sacs.

The pathogenesis of acne is complex. An interaction between hormones,keratinization, sebum, and bacteria somehow determines the course andseverity of the disease. Acne begins at puberty when the increase ofandrogens causes an increase in the size and activity of thepilosebaceous glands. The earliest microscopic change is intrafollicularhyperkeratosis, which leads to restriction of the pilosebaceous folliclewith consequent formation of the comedone composed of sebum, keratin,and microorganisms, particularly Propionibacterium (Corynebacterium)acnes. Lipases from P. acnes break down triglycerides in the sebum toform free fatty acids (FFA), which irritate the follicular wall.Retention of sebaceous secretions and dilation of the follicle may leadto cyst formation. Rupture of the follicle with release of the contentsinto the tissues induces an inflammatory reaction which heals withscarring in severe cases.

Acne tends to appear during puberty and to fade away again, usuallyspontaneously when growth has stopped. Only rarely does it recede beforethe age of 20 and occasionally it is still to be found at the age of 30and beyond. The face, back, and shoulders are the predominant areasaffected. Particularly with the face, severe cases can cause alterationsresulting in considerable disfigurement with significant psychologicalburdens for the afflicted person.

Acne can be treated by topical application of various lotions, salves,and the like or by, for example, localized treatment with sulphur,resorcinol, salicylic acid, benzoyl peroxide, vitamin A acids,antibiotics such as erythromycin, and the like.

Salicylic acid is a well recognized anti-acne active ingredient whichcauses a reduction in intercellular cohesion of the corneocytes (see, C.Huber et al., Arch. Derm. Res. 257, pp. 293-297, 1977). It has also beenpostulated that salicylic works by dissolving the existing keratin plugsas well as preventing the formation of new ones. In order to best exertits skin benefits, the ideal anti-acne composition should deliver andretain optimal concentrations of salicylic acid in the stratum corneumwith less penetration through the skin and into the general circulation.Also, compliance by the user to a regimen of treatment involvingrepeated applications is important. However, salicylic acid tends to besomewhat drying and irritating and can often cause peeling, therebycausing individuals to refrain from using salicylic acid products asfrequently and copiously as is necessary to obtain an optimum benefit.Thus, user compliance with current salicylic acid compositions is lessthan ideal.

Panthenol is the alcohol form of pantothenic acid, a well knownnutritional factor. The use of panthenol in skin care products, e.g.shampoos and skin creams is also known. It has been reported thatpanthenol, for example in combination with zinc oxide, provides anacceleration of superficial wound healing (see, H. Weise et al.,"Acceleration of Superficial Wound Healing by Panthenol Zinc Oxide",Cosmetics and Toiletries, vol. 103, pp. 79-84, October 1988).

It has been found in the instant invention that the combination ofsalicylic acid and pantothenic acid or a pantothenic acid derivative,preferably dexpanthenol, provides compositions which are effective forthe treatment of ache that are less irritating and drying to the skinthan conventional salicylic acid compositions. These compositions haveimproved user acceptance and thus promote better user compliance with aconcomitant overall improved anti-acne benefit. It has also been foundthat these compositions are useful for effacing and preventing wrinklesand atrophy in mammalian skin.

It is therefore an object of the present invention to provide methodsfor the treatment of acne in mammalian skin. Another object of thepresent invention is to provide methods for the treatment of acne whichare gentler, and thus less irritating and drying to the skin. A furtherobject of the present invention is to provide methods for the treatmentof acne utilizing a combination of the active ingredient salicylic acidwith pantothenic acid or a pantothenic acid derivative. An even furtherobject of the present invention is to provide methods for the treatmentof acne utilizing a combination of the active ingredient salicylic acidwith dexpanthenol. A still further object of the present invention is toprovide less irritating compositions for the treatment of acne. A yetfurther object of the present invention is to provide a method ofregulating wrinkles and/or atrophy in mammalian skin.

These and other objects of this invention will become apparent in lightof the following disclosure.

SUMMARY OF THE INVENTION

The present invention relates to a method for treating acne in mammalianskin comprising treating the skin with a safe and effective amount of acomposition comprising:

(a) from about 0.01% to about 20% salicylic acid,

(b) from about 0.1% to about 10% dexpanthenol, and

(c) a pharmaceutically-acceptable carrier.

The present invention furthers relates to a method for regulatingwrinkles and/or atrophy in mammalian skin.

All percentages and ratios used herein are by weight and allmeasurements are at 25° C., unless otherwise indicated.

DETAILED DESCRIPTION OF THE INVENTION

Salicylic Acid

An essential component of the compositions useful in the methods of theinstant invention is salicylic acid. Salicylic acid, which is also knownas 2-hydroxybenzoic acid is a white crystalline powder having a meltingpoint from about 157°-159 ° C. See The Merck Index, Tenth Edition, entry8190, p. 1200 (1983); U.S. Pat. No. 4,514,385, to Damani et al., issuedApr. 30, 1985; and 56 Federal Register, pp. 41008-41020, Aug. 16, 1991;these three references are incorporated herein by reference in theirentirety.

Without being limited by theory, it is believed salicylic acid providesits anti-acne benefit and its effect on skin wrinkles and/or atrophy viaits keratolytic activity.

The salicylic acid of the compositions useful in the instant inventionis present from about 0.01% to about 20%, more preferably from about0.1% to about 7%, and most preferably from about 0.5% to about 2%.

Pantothenic Acid and Pantothenic Acid Derivatives

Another essential component of the compositions useful in the methods ofthe instant invention is pantothenic acid and/or a pantothenic acidderivative. Pantothenic acid, which is also known asN-(2,4-dihydroxy-3,3-dimethylbutyryl)-B-alanine, is a member of the Bcomplex vitamins and is sometimes known as vitamin B₃. Pantothenic acidis a dietary essential for most mammals. The material can exist as theD(+) form, the L(-) form, and the racemate. However, only the naturalD(+) form has vitamin activity. See The Merck Index, Tenth Edition,entry 6877, p. 1007 (1983); this reference is incorporated herein byreference in its entirety.

A variety of pantothenic acid derivatives are known and or can besynthesized. Nonlimiting examples include the alcohol, aldehyde, alcoholesters, acid esters, and the like. Especially preferred for use in thecompositions of the instant invention is the alcohol derivative ofpantothenic acid. This alcohol, which is also known as panthenol,pantothenol, and2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide is a stablesource of pantothenic acid activity. Like the parent acid, panthenol canexist as the D(+) form, the L(-) form, and the racemate. However, onlythe D(+) form has vitamin activity. The D(+) form of panthenol, which ismore commonly known as dexpanthenol, is most preferred for use in theinstant invention. If however, the racemate is used, it may be necessaryto compensate for this factor since the racemate contains only 50% ofthe D(+) form. See The Merck Index, Tenth Edition, entry 2910, p. 426(1983); this reference is incorporated herein by reference in itsentirety.

The pantothenic acid and or pantothenic acid derivative of thecompositions useful in the instant invention is present from about 0.1%to about 10%, more preferably from about 0.5% to about 5%, and mostpreferably from about 1% to about 3.5%.

Preferred for use in these compositions is from about 0.1% to about 10%dexpanthenol, more preferably from about 1% to about 5%, and mostpreferably from about 1.5% to about 3.5%.

pH Requirements

The pH of a formulation is an important factor in the availability ofthe salicylic acid and the stability of the formulation. For example,without being limited by theory, at pH values above the pK_(a) ofsalicylic acid in a particular matrix, the salicylic acid would existprimarily in its ionized form and would not as readily penetrate intothe skin. The following pK_(a) values have been reported for salicylicacid: 2.98 (H₂ O) and 7.9 (ethanol). See CRC Handbook of Chemistry andPhysics, 57th Edition, 1976-1977, p. D-150; and Lange's Handbook ofChemistry, 13th Edition, 1985, p. 5-69, respectively. Without beinglimited by theory, in mixed alcohol water systems, it is believed thatthe pK_(a) value for salicylic acid would, in most cases fall betweenthese extremes. An acidic formulation range is preferred for salicylicacid compositions in order to supress ionization and enhance itspenetration into the stratum corneum.

A wide variety of acids, bases, and buffers can be utilized to adjustand/or maintain the pH of the compositions useful in the instantinvention. Although triethanolamine is preferred, other nonlimitingexamples of materials useful for adjusting and/or maintaining the pHinclude sodium carbonate, sodium hydroxide, hydrochloric acid,phosphoric acid, sodium hydrogen phosphate, sodium dihydrogen phosphate,citric acid, and the like.

The compositions useful in the instant invention preferably have a pHrange from about 2 to about 7, more preferably from about 2 to about6.5, even more preferably from about 2 to about 5.5, and most preferablyfrom about 2.5 to about 4.5.

Pharmaceutically-Acceptable Carriers

The compositions useful in the instant invention comprise a safe andeffective amount of a topical pharmaceutically-acceptable carrier ordiluent which can be of a variety of different forms. By "safe andeffective" is meant an amount sufficient to act as a suitable vehiclefor the required components and any other optional components, but notso much as to cause any side effects or skin reactions."Pharmaceutically-acceptable" means that the carrier is suitable fortopical application to the skin without causing any untoward safety ortoxicity concerns. In other words, these carriers are suitable for useon mammalian skin. The typical carrier can be in the form of ahydroalcoholic system (e.g. liquids and gels), an anhydrous oil orsilicone based system, or an emulsion system, including, but not limitedto, oil-in-water, water-in-oil, water-in-oil-in-water, andoil-in-water-in-silicone emulsions. The emulsions can cover a broadrange of consistencies including thin lotions (which can also besuitable for spray or aerosol delivery), creamy lotions, light creams,heavy creams, and the like. The emulsions can also include microemulsionsystems. Other suitable topical carriers include anhydrous solids andsemisolids (such as gels and sticks); and aqueous based mousse systems.Nonlimiting examples of the topical carrier systems useful in thepresent invention are described in the following four references, all ofwhich are incorporated herein by reference in their entirety: "SunProducts Formulary", Cosmetics & Toiletries, vol. 105, pp. 122-139(December 1990); "Sun Products Formulary", Cosmetics & Toiletries, vol.102, pp. 117-136 (March 1987); U.S. Pat. No. 4,960,764 to Figueroa etal., issued Oct. 2, 1990; and U.S. Pat. No. 4,254,105 to Fukuda et al.,issued Mar. 3, 1981.

The pharmaceutically-acceptable topical carriers, in total, typicallycomprise from about 0.1% to about 99.8% by weight of the compositionsuseful in the present invention, preferably from about 80% to about 99%,and most preferably from about 85% to about 95%.

An especially preferred pharmaceutically-acceptable topical carrieruseful in the instant invention is a hydroalcoholic system comprisingfrom about 1% to about 99% of ethanol, isopropanol, or mixtures thereof,and from about 1% to about 99% of water. More preferred is a carriercomprising from about 5% to about 60% of ethanol, isopropanol, ormixtures thereof, and from about 40% to about 95% of water. Especiallypreferred is a carrier comprising from about 20% to about 50% ofethanol, isopropanol, or mixtures thereof, and from about 50% to about80% of water.

Optional Components

In addition to the required components of the compositions useful in thepresent invention, a variety of optional components can also beincorporated.

Other Anti-Acne Agents

The compositions useful in the present invention can also contain otheranti-acne agents in addition to the salicylic acid.

These other anti-acne agents preferably comprise from about 0.1% toabout 20% by weight of the compositions useful herein, more preferablyfrom about 0.1% to about 10%, and most preferably from about 0.1% toabout 5%. Mixtures of these additional anti-acne actives may also beused.

Examples of these other anti-acne agents include keratolytics such assulfur, lactic acid, glycolic, pyruvic acid, urea, resorcinol, andN-acetylcysteine; retinoids such as retinoic acid and its derivatives(e.g., cis and trans); antibiotics, antimicrobials, antibacterials,antifungals, antiprotozoals, and antivirals (e.g., benzoyl peroxide,octopirox, erythromycin, tetracyclin, triclosan, azelaic acid and itsderivatives, phenoxy ethanol and phenoxy proponol, ethylacetate,clindamycin and meclocycline, triclosan, chlorhexidine, tetracycline,neomycin, miconazole hydrochloride, octopirox, parachlorometaxylenol,nystatin, tolnaftate, clotrimazole, and the like); sebostats such asflavinoids; hydroxy acids; antipruritic drugs inlcuding, for example,pharmaceutically-acceptable salts of methdilizine and trimeprazine; andbile salts such as scymnol sulfate and its derivatives, deoxycholate,and cholate.

Also, useful are non-steroidal anti-inflammatory drugs (NSAIDS). TheNSAIDS can be selected from the following categories: propionic acidderivatives; acetic acid derivatives; fenamic acid derivatives;biphenylcarboxylic acid derivatives; and oxicams. All of these NSAIDSare fully described in the U.S. Pat. No. 4,985,459 to Sunshine et al.,issued Jan. 15, 1991, incorporated by reference herein. Most preferredare the propionic NSAIDS including but not limited to aspirin,acetaminophen, ibuprofen, naproxen, benoxaprofen, flurbiprofen,fenoprofen, fenbufen, ketoprofen, indoprofen, pirprofen, carprofen,oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen,tiaprofenic acid, fluprofen and bucloxic acid. Also useful are thesteroidal anti-inflammatory drugs including hydrocortisone and the like.

Humectants/Moisturizers/Skin Conditioners

A highly preferred optional component of the compositions useful in theinstant invention is at least one humectant/moisturizer/skinconditioner. A variety of these materials can be employed and each canbe present at a level of from about 0.1% to about 20%, more preferablyfrom about 1% to about 10% and most preferably from about 2% to about5%. These materials include urea; guanidine; glycolic acid and glycolatesalts (e.g. ammonium and quaternary alkyl ammonium); lactic acid andlactate salts (e.g. ammonium and quaternary alkyl ammonium); aloe verain any of its variety of forms (e.g., aloe vera gel); polyhydroxyalcohols such as sorbitol, glycerol, hexanetriol, propylene glycol,hexylene glycol and the like; polyethylene glycol; sugars and starches;sugar and starch derivatives (e.g., alkoxylated glucose); hyaluronicacid; lactamide monoethanolamine; acetamide monoethanolamine; andmixtures thereof.

Preferred humectants/moisturizers/skin conditioners useful in thecompositions of the methods of the present invention are the C₃ -C₆diols and triols, and also aloe vera gel. Especially preferred is thetriol, glycerol, and also aloe vera gel.

Surfactants

The compositions useful in the methods of the present invention canoptionally comprise one or more surfactants. The surfactants can bepresent at a level from about 0.1% to about 10%, more preferably fromabout 0.2% to about 5%, and most preferably from about 0.2% to about2.5%. Suitable surfactants include, but are not limited to, nonionicsurfactants such as polyalkylene glycol ethers of fatty alcohols, andanionic surfactants such as taurates and alkyl sulfates. Nonlimitingexamples of these surfactants include isoceteth-20, sodium methyl cocoyltaurate, sodium methyl oleoyl taurate, and sodium lauryl sulfate. SeeU.S. Pat. No. 4,800,197, to Kowcz et al., issued Jan. 24, 1989, which isincorporated herein by reference in its entirety. Examples of a broadvariety of additional surfactants useful herein are described inMcCutcheon's, Detergents and Emulsifiers, North American Edition (1986),published by Allured Publishing Corporation, which is incorporatedherein by reference in its entirety.

Carboxylic Acid Copolymers

Another optional component of the compositions useful in the methods ofthe instant invention is a carboxylic copolymer (acrylic acidcopolymer). Most preferred is Carbomer 1342 (available as Carbopol 1342from B.F. Goodrich). These polymers are more fully described in U.S.Pat. No. 4,509,949, to Huang et al., issued Apr. 5, 1985, and U.S. Pat.No. 2,798,053, to Brown, issued Jul. 2, 1957, these patents both ofwhich are incorporated herein by reference in their entirety. Alsouseful are the acrylate/alkyl acrylate crosspolymers such asAcrylates/C10-C30 Alkyl Acrylate Crosspolymer (available as Pemulen TR-1and Pemulen TR-2 from Goodrich).

These polymers comprise from about 0.025% to about 0.75%, preferablyfrom about 0.05% to about 0.25% and most preferably from about 0.075% toabout 0.175% of the compositions useful herein.

Emollients

The compositions useful in the methods of the present invention can alsooptionally comprise at least one emollient. Examples of suitableemollients include, but are not limited to, volatile and non-volatilesilicone oils, highly branched hydrocarbons, and non-polar carboxylicacid and alcohol esters, and mixtures thereof. Emollients useful in theinstant invention are further described in U.S. Pat. No. 4,919,934, toDeckner et al., issued Apr. 24, 1990, which is incorporated herein byreference in its entirety.

The emollients can typically comprise in total from about 1% to about50%, preferably from about 1% to about 25%, and more preferably fromabout 1% to about 10% by weight of the compositions useful in thepresent invention.

Sunscreens

The compositions useful in the methods of the present invention can alsooptionally comprise at least one sunscreening agent. A wide variety ofone or more sunscreening agents are suitable for use in the presentinvention and are described in U.S. Pat. No. 5,087,445, to Halley etal., issued Feb. 11, 1992; U.S. Pat. No. 5,073,372, to Turner et al.,issued Dec. 17, 1991; U.S. Pat. No. 5,073,371, to Turner et al. issuedDec. 17, 1991; and Segarin, et al., at Chapter VIII, pages 189 et seq.,of Cosmetics Science and Technology, all of which are incorporatedherein by reference in their entirety.

Preferred among those sunscreens which are useful in the compositions ofthe instant invention are those selected from the group consisting ofethylhexyl p-methoxycinnamate, octocrylene, octyl salicylate,oxybenzone, and mixtures thereof.

Other useful sunscreens include the solid physical sunblocks such astitanium dioxide (micronized titanium dioxide, 0.03 microns), zincoxide, silica, iron oxide and the like. Without being limited by theory,it is believed that these inorganic materials provide a sunscreeningbenefit through reflecting, scattering, and absorbing harmful UV,visible, and infrared radiation.

Still other useful sunscreens are those disclosed in U.S. Pat. No.4,937,370, to Sabatelli, issued Jun. 26, 1990; and U.S. Pat. No.4,999,186, to Sabatelli et al., issued Mar. 12, 1991; these tworeferences are incorporated by reference herein in their entirety. Thesunscreening agents disclosed therein have, in a single molecule, twodistinct chromophore moieties which exhibit different ultra-violetradiation absorption spectra. One of the chromophore moieties absorbspredominantly in the UVB radiation range and the other absorbs stronglyin the UVA radiation range. These sunscreening agents provide higherefficacy, broader UV absorption, lower skin penetration and longerlasting efficacy relative to conventional sunscreens.

Generally, the sunscreens can comprise from about 0.5% to about 20% ofthe compositions useful herein. Exact amounts will vary depending uponthe sunscreen chosen and the desired Sun Protection Factor (SPF). SPF isa commonly used measure of photoprotection of a sunscreen againsterythema. See Federal Register, Vol. 43, No. 166, pp. 38206-38269, Aug.25, 1978, which is incorporated herein by reference in its entirety.

Other Optional Components

A variety of additional ingredients can be incorporated into thecompositions useful in the methods of the present invention.Non-limiting examples of these additional ingredients include othervitamins and derivatives thereof (e.g., ascorbic acid, vitamin E,tocopheryl acetate, and the like); thickening agents (e.g.polyacrylamide and C₁₃₋₁₄ isoparaffin and laureth-7, available asSepigel from Seppic Corporation); resins; gums; cationic polymers andthickeners (e.g., cationic guar gum derivatives such as guarhydroxypropyltrimonium chloride and hydroxypropyl guarhydroxypropyltrimonium chloride, available as the Jaguar C series fromRhone-Poulenc; copolymers of acrylamide and a cationic acrylate(available as Salcare SC92 from Allied Colloid); emulsifiers; polymersfor aiding the film-forming properties and substantivity of thecomposition (such as a copolymer of eicosene and vinyl pyrrolidone, anexample of which is available from GAF Chemical Corporation as GanexV-220^(R)); preservatives for maintaining the antimicrobial integrity ofthe compositions; skin penetration aids such as DMSO,1-dodecylazacycloheptan-2-one (available as Azone from the Upjohn Co.)and the like; artificial tanning agents such as dihydroxyacetone and thelike; skin bleaching (or lightening) agents including but not limited tohydroquinone, ascorbic acid, kojic acid and sodium metabisulfite;antioxidants; chelators and sequestrants; and aesthetic components suchas fragrances, pigments, colorings, essential oils, skin sensates,astringents, skin soothing agents, skin healing agents and the like,nonlimiting examples of these aesthetic components include clove oil,menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, witch hazeldistillate, allantoin, bisabalol, dipotassium glycyrrhizinate and thelike.

Delivery Methods for the Compositions

The compositions useful for the methods of the instant invention can bedelivered from a variety of delivery devices. The following are twononlimiting examples.

Medicated Cleansing Pads

The compositions useful herein can be incorporated into a medicatedcleansing pad. Preferably these pads comprise from about 50% to about75% by weight of one or more layers of nonwoven fabric material and fromabout 20% to about 75% by weight (on dry solids basis) of a watersoluble polymeric resin. These pads are described in detail in U.S. Pat.No. 4,891,228, to Thaman et al., issued Jan. 2, 1990 and U.S. Pat. No.4,891,227, to Thaman et al. issued Jan. 2, 1990; both of which areincorporated by reference herein in their entirety.

Dispensing Devices

The compositions useful herein can also be incorporated into anddelivered from a soft-tipped or flexible dispensing device. Thesedevices are useful for the controlled delivery of the compositions tothe skin surface and have the advantage that the treatment compositionitself never need be directly handled by the user. Nonlimiting examplesof these devices comprise a fluid container including a mouth, anapplicator, means for holding the applicator in the mouth of thecontainer, and a normally closed pressure-responsive valve forpermitting the flow of fluid from the container to the applicator uponthe application of pressure to the valve. The valve can include adiaphragm formed from an elastically fluid impermeable material with aplurality of non-intersecting arcuate slits therein, where each slit hasa base which is interesected by at least one other slit, and where eachslit is out of intersecting relation with its own base, and whereinthere is a meanns for disposing the valve in the container inside of theapplicator. Examples of these applicator devices are described in U.S.Pat. No. 4,693,623, to Schwartzman, issued Sep. 15, 1987; U.S. Pat. No.4,620,648, to Schwartzman, issued Sep. 15, 1987; U.S. Pat. No.3,669,323, to Harker et al., issued Jun. 13, 1972; U.S. Pat. No.3,418,055, to Schwartzman, issued Dec. 24, 1968; and U.S. Pat. No.3,410,645, to Schwartzman, issued Nov. 12, 1968; all of which areincorporated herein by reference in their entirety. Examples ofapplicators useful herein are commercially available from Dab-O-Matic,Mount Vernon, N.Y.

Methods for Treating Acne

The present invention relates to a method for treating acne in mammalianskin. Such a method comprises topically applying to the skin aneffective amount of a composition containing salicylic acid andpantothenic acid or a pantothenic acid derivative. The term "effectiveamount", as used herein, means an amount sufficient to provide ananti-acne benefit. Typically, an effective coating of the skin is fromabout 0.01 mg salicylic acid or composition of the present invention/cm²skin to about 5 mg salicylic acid or composition of the presentinvention/cm² skin. The composition can be continually applied atappropriate intervals, preferably about once or twice a day until theacne subsides.

Methods for Regulating Wrinkles and/or Skin Atrophy in Mammalian Skin

The present invention also relates to a method for regulating wrinklesand/or atrophy in mammalian skin. Such a method comprises treating theskin with a safe and effective amount of a composition containingsalicylic acid and panthothenic acid or a panthothenic acid derivative.The term "effective amount", as used herein, means an amount sufficientto provide a therapeutic effect. Typically, an effective coating of theskin is from about 0.01 mg salicylic acid or composition of the presentinvention/cm² skin to about 5 mg salicylic acid or composition of thepresent invention/cm² skin.

A preferred method of treating the skin is via chronic topicalapplication. By "chronic" application, it is meant herein that theperiod of topical application may be over the lifetime of the subjectthereby resulting in regulation of wrinkles and/or atrophy in mammalianskin.

EXAMPLES

The following examples further describe and demonstrate embodimentswithin the scope of the present invention. The examples are given solelyfor the purpose of illustration and are not to be construed aslimitations of the present invention, as many variations thereof arepossible without departing from the spirit and scope of the invention.

Ingredients are identified by chemical or CTFA name.

Example I

Composition

A topical composition is prepared by combining the following componentsutilizing conventional mixing techniques.

    ______________________________________                                        Ingredients        % Weight                                                   ______________________________________                                        Deionized Water    qs 100                                                     Ethanol (SD 40B Alcohol)                                                                         35.0                                                       Salicylic Acid     2.0                                                        Dexpanthenol       3.0                                                        ______________________________________                                    

In a suitable vessel the salicylic acid is dissolved in the ethanol withstirring. In a separate vessel the dexpanthenol is dissolved in thewater with stirring. The resulting alcohol and water solutions are thencombined with mixing.

This composition is useful for topical application for the treatment ofacne. Alternatively, this composition is useful for topical applicationto regulate skin wrinkles and/or skin atrophy.

Examples II-V

Composition

The following topical compositions are prepared by combining thefollowing components utilizing conventional mixing techniques.

    ______________________________________                                                       % Weight                                                       Ingredients      II      III     IV    V                                      ______________________________________                                        Deionized Water  qs 100  qs 100  qs 100                                                                              qs 100                                 Ethanol (SD 40B Alcohol)                                                                       35.0    35.0    20.0  35.0                                   Salicylic Acid   2.0     2.0     0.5   2.0                                    Dexpanthenol     3.0     3.0     1.0   3.0                                    Glycerol         2.0     2.0     --    --                                     Aloe Vera Gel    --      1.0     0.5   --                                     Menthol          --      --      0.05  --                                     Witch Hazel Distillate                                                                         --      --      5.0   --                                     Na Methyl Cocoyl Taurate or                                                                    --      --      1.0   --                                     Na Methyl Oleoyl Taurate                                                      Isoceteth-20     --      --      --    2.0                                    Quaternium-22    --      --      1.0   --                                     Disodium EDTA    0.005   0.005   0.005 0.005                                  Triethanolamine, 99%                                                                           0-1.0   0-1.0   --    0-1.0                                  ______________________________________                                    

In a suitable vessel the salicylic acid is dissolved in the ethanol withstirring. In a separate vessel the remaining ingredients except for thetriethanolamine are dissolved in the water with stirring. The resultingalcohol and water solutions are then combined with mixing. Next,sufficient triethanolamine is added as needed to adjust the pH tobetween about 2.5 to about 4.0.

These compositions are useful for topical application for the treatmentof acne. Alternatively, these compositions are useful for topicalapplication to regulate skin wrinkles and/or skin atrophy.

Example VI

Gel Composition

A topical composition is prepared by combining the following componentsutilizing conventional mixing techniques.

    ______________________________________                                        Ingredients        % Weight                                                   ______________________________________                                        Deionized Water    qs 100                                                     Ethanol (SD 40B Alcohol)                                                                         40.0                                                       Salicylic Acid     2.0                                                        Dexpanthenol       3.0                                                        Polyacrylamide and C.sub.13-14                                                                   4.0                                                        Isoparaffin and Laureth-7.sup.1                                               ______________________________________                                         .sup.1 Available as Sepigel from Seppic Corporation.                     

Water is added to a suitable vessel. While mixing at moderate speed (300rpm), the polyacrylamide isoparaffin and C₁₃₋₁₄ isoparaffin andlaureth-7 is added to the water. Next the dexpanthenol is added andmixed until dissolved. In a separate vessel, using a Lightnin' or otherappropriate mixer with a 3 blade paddle prop, the salicylic acid isadded to the ethanol and mixed until dissolved. The alcohol mixture isslowly added with mixing to the water phase to form a gel. The resultinggel is mixed at moderate speed until uniform.

This gel composition is useful for topical application for the treatmentof acne. Alternatively, this composition is useful for topicalapplication to regulate skin wrinkles and/or skin atrophy.

Example VII

Gel Composition

A topical composition is prepared by combining the following componentsutilizing conventional mixing techniques.

    ______________________________________                                        Ingredients        % Weight                                                   ______________________________________                                        Deionized Water    qs 100                                                     Ethanol (SD 40B Alcohol)                                                                         40.0                                                       Salicylic Acid     2.0                                                        Dexpanthenol       3.0                                                        Copolymer of Acrylamide and                                                                      3.0                                                        Cationic Acrylate.sup.1                                                       Menthol            0.05                                                       Disodium EDTA      0.05                                                       Glycerol           2.00                                                       ______________________________________                                         .sup.1 Available as Salcare SC92 from Allied Colloids.                   

Water is added to a suitable vessel. While mixing at moderate speed (300rpm), the copolymer of acrylamide and cationic acrylate is added to thewater. Next the remaining ingredients, except for the salicylic acid,are added and mixed until dissolved. In a separate vessel, using aLightnin' or other appropriate mixer with a 3 blade paddle prop, thesalicylic acid is added to the ethanol and mixed until dissolved. Thealcohol mixture is slowly added with mixing to the water phase to form agel. The resulting gel is mixed at moderate speed until uniform.

This gel composition is useful for topical application for the treatmentof acne. Alternatively, this composition is useful for topicalapplication to regulate skin wrinkles and/or skin atrophy.

Example VIII

A Pad of the present invention is made as follows:

    ______________________________________                                        Component          % Weight                                                   ______________________________________                                        Substrate A                                                                   Cellulose-based nonwoven.sup.1                                                                   100.0                                                      Substrate B                                                                   Polyester (denier = 6).sup.2                                                                     45.0                                                       Orlon (denier = 8).sup.3                                                                         15.0                                                       Styrene-butadiene resin.sup.4                                                                    40.0                                                       Laminate                                                                      Polyethylene Powder Melt.sup.5                                                                   100.0                                                      ______________________________________                                         .sup.1 Obtained from James River as Airtex Spec 382.                          .sup.2 Obtained from Eastern Chemical Company.                                .sup.3 Obtained from American Cyanamid.                                       .sup.4 Obtained from Reichold as tylac 68-500 (ratio of styrene to            butadiene 80:20).                                                             .sup.5 Obtained from Quantum Chemical as microthene powder.              

Substrate A has a basis weight of about 55 grams per square yard and aloft of about 35 mills. Substrate B has a basis weight of about 65 gramsper square yard and a loft of about 70 to 80 mills. The two materialsare laminated together by applying a thin coat of polyethylene powder toSubstrate A and heating with IR lamps. Substrate A and B are then joinedat a nip roll to compress and bond the materials. The resulting nonwovenfabric has a loft of about 90 to 100 mills. The resulting nonwovenfabric is then cut into an oval shape (5 cm×7 cm), or any other desiredshape.

The resulting oval pads are suitable for saturation with any of thecompositions described in Examples I-VII and are thus suitable for thetreatment of acne, or alternatively to regulate skin wrinkles and/orskin atrophy.

Example IX

A soft-tipped applicator product is prepared by placing any of thecompositions described in Examples I-VII in a dispensing device having areservoir. Such devices are described in the patents cited above, andare commercially available from Dab-O-Matic, Mount Vernon, N.Y.

The resulting dispensing products are useful for the treatment of acne,or alternatively to regulate skin wrinkles and/or skin atrophy.

What is claimed is:
 1. A method of regulating wrinkles or skin atrophyin mammalian skin comprising treating the skin with a safe and effectiveamount of a composition comprising:(a) from about 0.01% to about 20%salicylic acid; (b) from about 0.1% to about 10% dexpanthenol; and (c) apharmaceutically acceptable carrierwherein said carrier has a pH of fromabout 2 to about 6.5.
 2. A method of regulating wrinkles or skin atrophyin mammalian skin comprising treating the skin with a safe and effectiveamount of an irritation reducing composition comprising:(a) from about0.01% to about 20% salicylic acid; (b) from about 0.1% to about 10%dexpanthenol; and (c) a pharmaceutically acceptable carrierwherein saidcarrier has a pH of from about 2 to about 6.5.